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KMID : 0861020190340020001
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Korea Journal of Herbology
2019 Volume.34 No. 2 p.1 ~ p.14
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Inhibitory Activities of Rehmanniae Radix 30% Ethanol Extracton Acute Gastritis and Peptic Ulcers
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Bae Hye-Kyung
Seo Bu-Il
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Abstract
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Objective : This study was designed to evaluate the protective effect of Rehmanniae Radix Crudus (RC) in 150 mM HCl/ethanol induced acute gastritis mice.
Methods : ICR mice were divided into 5 groups (normal group, control group, 10 mg/kg sucralfate treated group, 50 mg/kg RC treated group, 100 mg/kg RC treated group, n=8). Normal group was not take any treatment. Control group induced gastritis 1 hour after ingestion of distilled water. 10 mg/kg sucralfate induced group was induced gastritis 1 hour after ingestion of distilled of sucralfate 10 mg/kg. 50 mg/kg and 100 mg/kg RC treated groups were induced gastritis 1 hour after ingestion of distilled of RC 50 mg/kg and 100 mg/kg. After 1 hour of gastritis induction, removed the stomach tissue. We examined histological observations, oxidative stress biomarkers, antioxidant proteins, inflammatory mediators and cytokines.
Results : In this study, the RC treatment group showed gastritis and gastric ulcer inhibition, and the area of ??injury decreased. The oxidative stress biomarkers such as reactive oxygen species (ROS) and peroxy nitrite (ONOO-) in the serum were reduced in the RC treated group. Inaddition, antioxidant proteins (nuclear factor erythroid 2-related factor 2, Heme oxygenase 1) were increased in RC treated group, and the expression of inflammatory mediators and cytokines induced by nuclear factor-kappa B activation was inhibited.
Conclusion : According to the results, RC may have an excellent inhibitory effect on acute gastritis and gastric ulcer.
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KEYWORD
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Rehmanniae Radix Crudus, Gastritis, Anti-inflammatory effect , Oxidative stress
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